Published Articles

The following is a list of articles published all or in part by the Tang Center for Herbal Medicine Research.


2017

  1. Wang, L., Wang, X., Zhang, S.L., Zhu, X.M., Liu, Y.Q., Song, Z.J., Du, W.J., Ji, J., Cui, C.L., He, X., Zhang, C.F., Guo, C.R., Wang, C.Z., Yuan, C.S. 2017. Gastroprotective effect of palmatine against acetic acid-induced gastric ulcers in rats. J. Nat. Med. 71: 257-264.
  2. Hasebe, T., Matsukawa, J., Ringus, D., Miyoshi, J., Hart, J., Kaneko, A., Yamamoto, M., Kono, T., Fujiya, M., Kohgo, Y., Wang, C.Z., Yuan, C.S., Bissonnette, M., Musch, M.W., Chang, E.B. 2017. Daikenchuto (TU-100) suppresses tumor development in the azoxymethane and APCmin/+ mouse models of experimental colon cancer. Phytother. Res. 31: 90-99.
  3. Dai, D., Zhang, C.F., Williams, S., Yuan, C.S., Wang, C.Z. 2017. Ginseng on cancer: Potential role in modulating inflammation-mediated angiogenesis. Am. J. Chin. Med. 45: 13-22.
  4. Yuan, J., Ren, G., Liang, J., Wang, C.Z., Yan, Z., Huang, Q., Li, J., Chen, Y., Tang, Y., Liu, X., Yuan, C.S. 2017. Comparative studies on the multi-component pharmacokinetics of Aristolochiae Fructus and honey-fried Aristolochiae Fructus extracts after oral administration in rats. BMC Complement. Altern. Med. 17: 107.
  5. Wang, L., Wang, X., Zhu, X.M., Liu, Y.Q., Du, W.J., Ji, J., He, X., Zhang, C.F., Li, F., Guo, C.R., Wang, C.Z., Yuan, C.S. 2017. Gastroprotective effect of alkaloids from Cortex Phellodendri on gastric ulcers in rats through neurohumoral regulation. Planta Med. 83: 277-284.

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2016

  1. Wan, J.Y., Wang, C.Z., Liu, Z., Zhang, Q.H., Musch, M.W., Bissonnette, M., Chang, E.B., Li, P., Qi, L.W., Yuan, C.S. 2016. Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1015-1016: 62-73.
  2. Wang, C.Z., Anderson, S., Du, W., He, T.C., Yuan, C.S. 2016. Red ginseng and cancer treatment. Chin. J. Nat. Med. 14: 7-16.
  3. Du, W.J., Yang, X.L., Song, Z.J., Wang, J.Y., Zhang, W.J., He, X., Zhang, R.Q., Zhang, C.F., Li, F., Yu, C.H., Wang, C.Z., Yuan, C.S. 2016. Antitumor activity of total flavonoids from Daphne genkwa in colorectal cancer. Phytother. Res. 30: 323-330.
  4. Wang, C.Z., Anderson, S., Yuan, C.S. 2016. Phytochemistry and anticancer potential of notoginseng. Am. J. Chin. Med. 44: 23-34.
  5. Wang, J., Ji, J., Song, Z., Zhang, W., He, X., Li, F., Zhang, C., Guo, C., Wang, C., Yuan, C. 2016. Hypocholesterolemic effect of emodin by simultaneous determination of in vitro and in vivo bile salts binding. Fitoterapia 110: 116-122.
  6. Li, H., He, H.L., Huang, J.J., Wang, C.Z., Gu, X.L., Gao, Y.K., Zhang, H.J., Du, S.H., Chen, L.N., Yuan, C.S. 2016. A novel molecularly imprinted method with computational simulation for the affinity isolation and knockout of baicalein from Scutellaria baicalensis. Biomed. Chromatogr. 30: 117-125.
  7. Chen, M.Y., Tang, Y.J., Wang, Y.C., Wang, C.Z., Yuan, C.S., Chen, Y., Tan, Z.R., Huang, W.H., Zhou, H.H. 2016. Quantitative determination of betamethasone sodium phosphate and betamethasone dipropionate in human plasma by UPLC-MS/MS and a bioequivalence study. Anal. Methods 8: 3550-3563.
  8. Zhang, Q.H., Zhou, L.D., Chen, H., Wang, C.Z., Xia, Z.N., Yuan, C.S. 2016. Solid-phase microextraction technology for in vitro and in vivo metabolite analysis. Trends Analyt. Chem. 80: 57-65.
  9. Ma, W.K., Li, H., Dong, C.L., He, X., Guo, C.R., Zhang, C.F., Yu, C.H., Wang, C.Z., Yuan, C.S. 2016. Palmatine from Mahonia bealei attenuates gut tumorigenesis in ApcMin/+ mice via inhibition of inflammatory cytokines. Mol. Med. Rep. 14: 491-498.
  10. Liu, Z., Xia, J., Wang, C.Z., Zhang, J.Q., Ruan, C.C., Sun, G.Z., Yuan, C.S. 2016. Remarkable impact of acidic ginsenosides and organic acids on ginsenoside transformation from fresh ginseng to red ginseng. J. Agric. Food Chem. 64: 5389-5399.
  11. Yuan, J., Chen, Y., Liang, J., Wang, C.Z., Liu, X., Yan, Z., Tang, Y., Li, J., Yuan, C.S. 2016. Component analysis and target cell-based neuroactivity screening of Panax ginseng by ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1038: 1-11.
  12. Tung, N.H., Wang, C.Z., Du, G.J., Yuan, C.S., Uto, T., Shoyama, Y. 2016. Chemopreventive activity of naphthoquinones from Alkanna tinctoria (L.) Tausch in human colorectal cancer cells. J. Gastroenterol. Hepatol. Res. 5: 2115-2121.
  13. Shao, L., Nie, M.K., Chen, M.Y., Wang, J., Wang, C.Z., Huang, W.H., Yuan, C.S., Zhou, H.H. 2016. Screening and identifying antioxidants from Oplopanax elatus using 2,2'-diphenyl-1-picrylhydrazyl with off-line two-dimensional HPLC coupled with diode array detection and tandem time-of-flight mass spectrometry. J. Sep. Sci. 39: 4269-4280.
  14. Zhang, W.J., Dong, C.L., Wang, J.Y., He, X., Yang, X.L., Fu, Y.F., Zhang, C.F., Li, F., Wang, C.Z., Yuan, C.S. 2016. Thermal effects on the dissolution enhancement of Radix scutellariae by wine-processing. Appl. Therm. Eng. 103: 522-527.
  15. Wang, C.Z., Yu, C., Wen, X.D., Chen, L., Zhang, C.F., Calway, T., Qiu, Y., Wang, Y., Zhang, Z., Anderson, S., Wang, Y., Jia, W., Yuan, C.S. 2016. American ginseng attenuates colitis-associated colon carcinogenesis in mice: Impact on gut microbiota and metabolomics. Cancer Prev. Res. 9: 803-811.

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2015

  1. Zhang, Z., Li, Z., Wu, X., Zhang, C.F., Calway, T., He, T.C., Du, W., Chen, J., Wang, C.Z. and Yuan, C.S.  2015.  TRAIL pathway is associated with inhibition of colon cancer by protopanaxadiol.  J. Pharmacol. Sci. 127: 83-91.
  2. Yu, C., Wen, X.W., Zhang, Z., Zhang, C.F., Wu, X.H., Martin, A., Du, W., He, T.C., Wang, C.Z. and Yuan, C.S.  2015.  American ginseng attenuates azoxymethane/dextran sodium sulfate-induced colon carcinogenesis in mice.  J. Ginseng Res. 39: 14-21.
  3. Yu, C., Wen, X.D., Zhang, Z., Zhang, C.F., Wu, X., He, X., Liao, Y., Wu, N., Wang, C.Z., Du, W., He, T.C. and Yuan, C.S.  2015.  American ginseng significantly reduced the progression of high-fat-diet-enhanced colon carcinogenesis in Apc (Min/+) mice.  J. Ginseng Res. 39: 230-237.
  4. Wang, C.Z., Zhang, Z., Wan, J.Y., Zhang, C.F., Anderson, S., He, X., Yu, C., He, T.C., Qi, L.W. and Yuan, C.S.  2015.  Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer.  Nutrients 7: 799-814.
  5. Wang, C.Z., Cai, Y., Anderson, S. and Yuan, C.S.  2015.  Ginseng metabolites on cancer chemoprevention: An angiogenesis link?  Diseases 3: 193-204.
  6. Xie, G., Wang, C.Z., Yu, C., Qiu, Y., Wen, X.D., Zhang, C.F., Yuan, C.S. and Jia, W.  2015.  Metabonomic profiling reveals cancer chemopreventive effects of American ginseng on colon carcinogenesis in ApcMin/+ Mice.  J. Proteome. Res. 14: 3336-3347.
  7. Qi, L.W., Zhang, Z., Zhang, C.F., Anderson, S., Liu, Q., Yuan, C.S. and Wang, C.Z.  2015.  Anti-colon cancer effects of 6-shogaol through G2/M cell cycle arrest by p53/p21-cdc2/cdc25A crosstalk.  Am. J. Chin. Med. 43: 743-756.
  8. Wang, C.Z., Qi, L.W. and Yuan, C.S.  2015.  Cancer chemoprevention effects of ginger and its active constituents: Potential for new drug discovery.  Am. J. Chin. Med. 43: 1351-1363.
  9. Wang, C.Z., Zhang, C.F., Chen, L, Anderson, S., Lu, F. and Yuan, C.S.  2015.  Colon cancer chemopreventive effects of baicalein, an active enteric microbiome metabolite from baicalin.  Int. J. Oncol. 47: 1749-1758.
  10. Wang, X., Song, Z.J., He, X., Zhang, R.Q., Zhang, C.F., Li, F., Wang, C.Z. and Yuan, C.S.  2015.   Antitumor and immunomodulatory activity of genkwanin on colorectal cancer in the APCMin/+ mice.  Int. Immunopharmacol. 29: 701-707.
  11. Tanaka, T., Mori, T., Yuan, C.S., Soed, S., Tung, N.H. and Shoyama, Y.  2015.  The function of saffron and its constituent in gastroenterological tissues.  Global J. Gastroenterol. Hepatol. 3: 31-38.
  12. Li, H., Song, Z.J., Dai, Y.P., Zhang, S.L., He, X., Guo, C.R., Zhang, W.J., Wang, J.Y., Zhang, C.F., Wang, C.Z. and Yuan, C.S.  2015.  Antioxidative activity of flavonoids from Abrus cantoniensis against ethanol-induced gastric ulcer in mice.  Planta Med. 81: 784-790.
  13. Wu, X.H., Wang, C.Z., Wang, S.Q., Mi, C., He, Y., Zhang, J., Zhang, Y.W., Anderson, S. and Yuan, C.S.  2015.  Anti-hyperuricemia effects of allopurinol are improved by Smilax riparia, a traditional Chinese herbal medicine.  J. Ethnopharmacol. 162: 362–368.
  14. Lian, F., Wu, L., Tian, J., Jin, M., Zhou, S., Zhao, M., Wei, L., Zheng, Y., Wang, Y., Zhang, M., Qin, W., Wu, Z., Yuan, C.S. and Tong, X.  2015.  The effectiveness and safety of a danshen-containing Chinese herbal medicine for diabetic retinopathy: A randomized, double-blind, placebo-controlled multicenter clinical trial.  J. Ethnopharmacol. 164: 71–77.
  15. Lian, F., Tian, J., Chen, X., Li, Z., Piao, C., Guo, J., Ma, L., Zhao, L., Xia, C., Wang, C.Z., Yuan, C.S. and Tong, X.  2015.  The efficacy and safety of Chinese herbal medicine Jinlida as add-on medication in type 2 diabetes patients ineffectively managed by metformin monotherapy: A double-blind, randomized, placebo-controlled, multicenter trial.  PLoS One 10(6): e0130550.
  16. He, Y.S., Sun, W., Wang, C.Z., Qi, L.W., Yang, J., Li, P., Wen, X.D. and Yuan, C.S.  2015.  Effects of American ginseng on pharmacokinetics of 5-fluorouracil in rats.  Biomed. Chromatogr. 29: 762-767.
  17. Gu, X., He, H., Wang, C.Z., Gao, Y., Zhang, H., Hong, J., Du, S., Chen, L. and Yuan, C.S.  2015.  Synthesis of surface nano-molecularly imprinted polymers for sensitive baicalin detection in biological samples.  RSC Adv. 5: 41377-41384.
  18. Zhang, W.J., Wang, J.Y., Li, H., He, X., Zhang, R.Q., Zhang, C.F., Li, F., Yang, Z.L., Wang. C.Z. and Yuan CS.  2015.  Novel application of natural anisole compounds as enhancers for transdermal delivery of ligustrazine.  Am. J. Chin. Med. 43: 1231-1246.
  19. Huang, W.H., Zhang, Q.W., Wang, C.Z., Yuan, C.S. and Li, S.P.  2015.  Phenolic derivatives from the root bark of Oplopanax horridusHelv. Chim. Acta 98: 201-209.
  20. Yang, F.Q., Yuan, C.S., Tan, S.N. and Gao, J.L.  2015.  The complementary and alternative medicine for antithrombosis.  Evid. Based Complement. Alternat. Med. 2015: 791503.
  21. Wang, C.Z., Yuan, C.S. and Moss, J.  2015.  Anesthetic implications of complementary and alternative medications.  In: Miller’s Anesthesia, 8th Edition, (Miller, R.D. ed.) Elsevier Saunders: Philadelphia. p. 1226-1239.
  22. Wang, C.Z., Moss, J. and Yuan, C.S.  2015.  Commonly used dietary supplements on coagulation function during surgery.  Medicines 2: 157-185.

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2014

  1. Lin, D.H., Wang, C.Z., Qin, L.F., Xie, X.X., Wang, J.T., Gu, M., McEntee, E. and Yuan, C.S. 2014. Bioavailability of oral methylnaltrexone increases with a phosphatidylcholine based formulation. Drug Dev. Ind. Pharm. 40:186-191.
  2. Wen, X.D., Wang, C.Z., Yu, C., Zhao, L., Zhang, Z., Matin, A., Wang, Y., Li, P., Xiao, S.Y., Du, W., He, T.C. and Yuan. C.S. 2014. Panax notoginseng attenuates experimental colitis in the azoxymethane/dextran sulfate sodium mouse model. Phytother. Res. 28: 892-898.
  3. Lian, F., Li, G., Chen, X., Wang, X., Piao, C., Wang, J., Hong, Y., Ba, Z., Wu, S., Zhou, X., Lang, J., Liu, Y., Zhang, R., Hao, J., Zhu, Z., Li, H., Liu, H.F., Cao, A., Yan, Z., An, Y., Bai, Y., Wang, Q., Zhen, Z., Yu, C., Wang, C.Z., Yuan, C.S. and Tong, X. 2014. Chinese herbal medicine Tianqi reduces progression from impaired glucose tolerance to diabetes: A double-blind, randomized, placebo-controlled, multicenter trial. J. Clin. Endocrinol. Metab. 99: 648-655.
  4. Jiang, C.P., He, X., Yang, X.L., Zhang, S.L., Li, H., Song, Z.J., Zhang, C.F., Yang, Z.L., Li, P., Wang, C.Z. and Yuan, C.S. 2014. Anti-rheumatoid arthritic activity of flavonoids from Daphne genkwa. Phytomedicine 21: 830-837.
  5. Huang, W.H., Zhang, Q.W., Yuan, C.S., Wang, C.Z., Li, S.P., Zhou, H.H. 2014. Chemical constituents of the plants from the genus oplopanax. Chem. Biodivers. 11: 181-196.
  6. Zhang, C.F., Zhang, S.L., He, X., Yang, X.L., Wu, H.T., Lin, B.Q., Jiang, C.P., Wang, J., Yu, C.H., Yang, Z.L., Wang, C.Z., Li, P., Yuan, C.S. 2014. Antioxidant effects of Genkwa flos flavonoids on Freund's adjuvant-induced rheumatoid arthritis in rats. J. Ethnopharmacol. 153: 793-800.
  7. Jin, H.R., Liao, Y., Li, X., Zhang, Z., Zhao, J., Wang, C.Z., Huang, W.H., Li, S.P., Yuan, C.S. and Du, W. 2014. Anticancer compound oplopantriol A kills cancer cells through inducing ER stress and BH3 proteins Bim and Noxa. Cell Death Dis. 5: e1190.
  8. Huang, W.H., Shao, L., Wang, C.Z., Yuan, C.S. and Zhou, H.H. 2014. Anticancer activities of polyynes from the root bark of Oplopanax horridus and their acetylated derivatives. Molecules 19: 6142-6162.
  9. Ueno, N., Hasebe, T., Kaneko, A., Yamamoto, M., Fujiya, M., Kohgo, Y., Kono, T., Wang, C.Z., Yuan, C.S., Bissonnette, M., Chang, E.B. and Musch, M.W. 2014. TU-100 (Daikenchuto) and ginger ameliorate anti-CD3 antibody induced T cell-mediated murine enteritis: Microbe-independent effects involving Akt and NF-κB suppression. PLoS One 9: e97456.
  10. Zhang, Z., Yu, C., Zhang, C.F., Wu, X.H., Wen, X.D., Anderson, S., Du, W., Huang, W.H., Li, S.P., Wang, C.Z. and Yuan, C.S. 2014. Chemopreventive effects of oplopantriol A, a novel compound isolated from Oplopanax horridus, on Colorectal Cancer. Nutrients 6: 2668-2680.
  11. Yu, C., Wang, C.Z., Zhou, C.J., Wang, B., Han, L., Zhang, C.F., Wu, X.H. and Yuan, C.S. 2014. Adulteration and cultivation region identification of American ginseng using HPLC coupled with multivariate analysis. J. Pharm. Biomed. Anal. 99C: 8-15.
  12. Yang, Z.M., Zhao, J., Lao, K.M., Chen, X.J., Leong, F., Wang, C.Z., Yuan, C.S. and Li, S.P. 2014. Determination of six polyynes in Oplopanax horridus and Oplopanax elatus using polyethylene glycol modified reversed migration microemulsion electrokinetic chromatography. Electrophoresis 35: 2959-2964.
  13. Wu, X.H., Wang, C.Z., Zhang, J., Wang, S.Q., Han, L., Zhang, Y.W., Yuan, C.S. 2014. Effects of smilaxchinoside A and smilaxchinoside C, two steroidal glycosides from Smilax riparia, on hyperuricemia in a mouse model. Phytother. Res. 28: 1822-1828.
  14. Zhang, S.L., Li, H., He, X., Zhang, R.Q., Sun, Y.H., Zhang, C.F., Wang, C.Z. and Yuan, C.S. 2014. Alkaloids from Mahonia bealei possess anti-H(+)/K(+)-ATPase and anti-gastrin effects on pyloric ligation-induced gastric ulcer in rats. Phytomedicine 21: 1356-1363.
  15. Huang, W.H., Luo, W., Wang, C.Z., Yuan, C.S., Nie, M.K., Shi, S.Y., Zhou, H.H. and Ouyang, D.S. 2014. Phenolic constituents from Oplopanax horridus. Chin. J. Chin. Mat. Med. 39: 1852-1857.
  16. Bakshi, R.P., Brown, T.T., Simmons, A., Yuan, C.S., Bauer, B.A., Sloan, J.A. and Andrade, A. 2014. American ginseng (Panax quinquefolius) administration does not affect performance of the Roche COBAS Ampliprep/Taqman HIV-1 RNA assay. BMC Complement. Altern. Med.14:427.
  17. Wang, C.Z., Anderson, S. and Yuan, C.S. 2014. Advances in ginseng pharmacology: Enteric microbiome metabolite and metabolomic studies in cancer chemoprevention. Evidence-based Efficacy of Ginseng 2014, Proc. 11th Int. Symp. Ginseng p. 32-39.
  18. Shao, L., Bao, M.H., Ouyang, D.S., Wang, C.Z., Yuan, C.S., Zhou, H.H. and Huang, W.H. 2014. Unstable simple volatiles and gas chromatography-tandem mass spectrometry analysis of essential oil from the roots bark of Oplopanax horridus extracted by supercritical fluid extraction. Molecules 19: 19708-19717.
  19. Wang, C.Z., Zhang, Z., Anderson, S. and Yuan, C.S. 2014. Natural products and chemotherapeutic agents on cancer: Prevention vs. treatment. Am. J. Chin. Med. 42: 1555-1558.

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2013

  1. Tung, N., Du, G.J., Wang, C.Z., Yuan, C.S. and Shoyama, Y. 2013. Naphthoquinone components from Alkanna tinctoria (L.) Tausch show significant antiproliferative effects on human colorectal cancer cells. Phytother Res. 27: 66-70.
  2. Wang, C.Z., Calway, T.D., Wen, X.D., Smith, J., Yu, C., Wang, Y., Mehendale, S.R. and Yuan, C.S. 2013. Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. Int. J. Oncol. 42: 1018-1026.
  3. Du, G.J., Wang, C.Z., Qi, L.W., Zhang, Z.Y., Calway, T., He, T.C., Du, W. and Yuan, C.S. 2013. The Synergistic apoptotic interaction of panaxadiol and epigallocatechin gallate in human colorectal cancer cells. Phytother Res. 27: 272-277.
  4. Tong, X.L., Wu, S.T., Lian, F.M., Zhao, M., Zhou, S.P., Chen, X.Y., Yu, B., Zhen, Z., Qi, L.W., Li, P., Wang, C.Z., Sun, H. and Yuan, C.S. 2013. The safety and effectiveness of TM81, a Chinese herbal medicine, in the treatment of type 2 diabetes: A randomized double-blind placebo-controlled trial. Diabetes Obes. Metab. 15:448-454.
  5. Li, Z., Zhang, Z., Li, Y., Arnovitz, S., Chen, P., Huang, H., Jiang, X., Hong, G.M., Kunjamma,R.B., Ren, H., He, C., Wang, C.Z., Elkahloun, A.G., Valk, P.J., Döhner, K.,Neilly, M.B., Bullinger, L., Delwel, R., Lowenberg, B., Liu, P.P., Morgan, R., Rowley, J.D., Yuan, C.S. and Chen, J. 2013. PBX3 is an important cofactor of HOXA9 in leukemogenesis. Blood 121: 1422-1431.
  6. Wang, C.Z., Li, B., Wen, X.D., Zhang, Z., Yu, C., Calway, T.D., He, T.C., Du, W. and Yuan, C.S. 2013. Paraptosis and NF-kappaB activation are associated with protopanaxadiol-induced cancer chemoprevention. BMC Complement. Altern. Med. 13: 2 (1-10).
  7. Zhang, Z., Wang, C.Z., Wen, X.D., Shoyama, Y. and Yuan, C.S. 2013. Role of saffron and its constituents on cancer chemoprevention. Pharm. Biol. 51: 920-924.
  8. Zhang, Z., Du,G.J., Wang, C.Z., Wen, X.D., Calway, T., Li, Z., He, T.C., Du, W., Bissonnette, M., Musch, M.W., Chang, E.B. and Yuan, C.S. 2013. Compound K, a ginsenoside metabolite, inhibits colon cancer growth via multiple pathways including p53-p21 interactions. Int. J. Mol. Sci. 14: 2980-2995.
  9. Wan, J.Y., Liu, P., Wang, H.Y., Qi, L.W., Wang, C.Z., Li, P. and Yuan, C.S. 2013. Biotransformation and metabolic profile of American ginseng saponinswith human intestinal microflora by liquid chromatography quadrupole time-of-flight mass spectrometry. J. Chromatogr. A. 1286: 83-92.
  10. Gao, J.L., Lv,G.Y., He, B.C., Zhang, B.Q., Zhang, H., Wang, N., Wang, C.Z., Du, W., Yuan, C.S. and He, T.C. 2013. Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways. Oncol. Rep. 30: 292-298.
  11. Yu, C., Qu, F., Mao, Y., Li, D., Zhen, Z., Nass, R., Calway, T., Wang, Y., Yuan, C.S. and Wang, C.Z. 2013. Different extraction pretreatments significantly change the flavonoid contents of Scutellaria baicalensis. Pharm. Biol. 51: 1228-1235.
  12. Zhang, Z., Wang, C.Z., Du, G.J., Qi, L.W., Calway, T., He, T.C., Du, W. and Yuan. C.S. 2013. Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells. Int. J. Oncol. 43: 289-296.
  13. Wang, C.Z., Zhang, Z., Huang, W.H., Du, G.J., Wen, X.D., Calway, T., Yu, C., Nass, R., Zhao, J., Du, W., Li, S.P. and Yuan, C.S. 2013. Identification of potential anticancer compounds from Oplopanax horridus. Phytomedicine 20: 999-1006.
  14. Yu, C.H., Wang, C.Z. and Yuan, C.S. 2013. Progress in anti-cancer research of American ginseng: with an example of colorectal cancer. Acta Pharm. Sin. 48: 986-992.
  15. Wen, X.D., Wang, C.Z., Yu, C., Zhang, Z., Calway, T., Wang, Y., Li, P. and Yuan, C.S. 2013. Salvia miltiorrhiza (Dan Shen) significantly ameliorates colon inflammation indextran sulfate sodium induced colitis. Am. J. Chin. Med. 41 :1097-1108.
  16. Huu Tung, N.H., Du, G.J., Yuan, C.S., Shoyama, Y. and Wang, C.Z. 2013. Isolation and chemopreventive evaluation of novel naphthoquinone compounds from Alkanna tinctoria. Anticancer Drugs 24: 1058-1068.
  17. Wang, C.Z. and Yuan, C.S. 2013. Pharmacologic treatment of opioid-induced constipation. Expert Opin. Investig. Drugs 10: 1225-1227.
  18. Yu, C., Zhang, Z., Zhang, H., Zhen, Z., Calway, T., Wang, Y., Yuan, C.S. and Wang, C.Z. 2013. Pretreatment of baicalin and wogonoside with glycoside hydrolase: A promising approach to enhance anticancer potential. Oncol. Rep. 30: 2411-2418.

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2012

  1. Wang, C.Z., Du, G.J., Zhang, Z., Wen, X.D., Calway, T., Zhen, Z., Musch, M.W., Bissonnette, M., Chang, E.B. and Yuan, C.S. 2012. Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer. Int. J. Oncol. 40: 1970-1976.
  2. Du, G.J., Wang, C.Z., Zhang, Z.Y., Wen, X.D., Somogyi, J., Calway, T., He, T.C., Du, W. and Yuan, C.S. 2012. Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells. J. Pharm. Pharmacol. 64: 727-734.
  3. Wang, C.Z., Calway, T. and Yuan, C.S. 2012. Herbal medicines as adjuvants for cancer therapeutics. Am. J. Chin. Med. 40: 657-669.
  4. Calway, T., Du, G.J., Wang, C.Z., Huang, W.H., Zhao, J., Li, S.P. and Yuan, C.S. 2012. Chemical and pharmacological studies of Oplopanax horridus, a North American botanical. J. Nat. Med. 66: 249-256.
  5. Jin, H.R., Zhao, J., Zhang, Z., Liao, Y., Wang, C.Z., Huang, W.H., Li, S.P., He, T.C., Yuan, C.S. and Du, W. 2012. The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress. Cell Death Dis. 3: e376.
  6. Du, G.J., Zhang, Z., Wen, X.D., Yu, C., Calway, T., Yuan, C.S. and Wang, C.Z. 2012. Epigallocatechin Gallate (EGCG) is the most effective cancer chemopreventive polyphenol in green tea. Nutrients 8: 1679-1691.
  7. Li, J., Shao, Z.H., Xie, J.T., Wang, C.Z., Ramachandran, S., Yin, J.J., Aung, H., Li, C.Q., Qin, G., Vanden Hoek, T., Yuan. C.S. 2012. The effects of ginsenoside Rb1 on JNK in oxidative injury in cardiomyocytes. Arch. Pharm. Res. 35: 1259-1267.
  8. Yuan, C.S., Wang, C.Z. and Qi, L.W. 2012. Current status of traditional Chinese medicine research in the U.S. and the American Journal of Chinese Medicine. Proc. 4th World Integrat. Med. Congr. p. 34-36.
  9. Yuan, C.S. 2012. Multiple constituents and multiple actions of ginseng. Proc. 2012 Int. Conf. Ginseng p. 30-39.
  10. Wang, C.Z., He, H., Wang, X. and Yuan, C.S. 2012. Trends in scientific publications of Chinese medicine. Am. J. Chin. Med. 40: 1099-1108.
  11. Ma, R.H., Yang, J., Qi, L.W., Xin, G.Z., Wang, C.Z., Yuan, C.S., Wen, X.D. and Li, P. 2012. In vivo microdialysis with LC-MS for analysis of spinosin and its interaction with cyclosporin A in rat brain, blood and bile. J. Pharm. Biomed. Anal. 61: 22-29
  12. Kwon, S.T., Uto, T., Morinaga, O., Nguyen, T.N., Tanaka, H., Yuan, C.S. and Shoyama, Y. 2012. A new strategy of immunostaining for identification of ginsenosides. Int. J. Biomed. Pharmaceut. Sci. 6: S100-S105.
  13. Qi, L.W., Wang, H.Y., Zhang, H., Wang, C.Z., Li, P. and Yuan, C.S. 2012. Diagnostic ion filtering to characterize ginseng saponins by rapid liquid chromatography with time-of-flight mass spectrometry. J. Chromatogr. A 1230: 93-99.
  14. Wen, X.D., Yang, J., Ma, R.H., Gao, W., Qi, L.W., Li, P., Bauer, B.A., Du, G.J., Zhang, Z., Somogyi, J., Wang, C.Z. and Yuan, C.S. 2012. Analysis of Panax notoginseng metabolites in rat bile by liquid chromatography-quadrupole time-of-flight mass spectrometry with microdialysis sampling. J. Chromatogr. B 895-896:162-168.
  15. Wen, X.D., Liu, E.H., Yang, J., Li, C.Y., Gao, W., Qi, L.W., Wang, C.Z., Yuan, C.S. and Li, P. 2012. Identification of metabolites of Buyang Huanwu decoction in rat urine using liquid chromatography-quadrupole time-of-flight mass spectrometry. J. Pharm. Biomed. Anal. 67-68:114-1122.
  16. Wang, C.Z., Li, P. and Yuan, C.S. 2012. Traditional Chinese herbal therapy as a treatment option for H1N1 influenza. Ann. Intern. Med. 156: 166-167.

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2011

  1. Li, B., Zhao, J. Wang, C.Z., Searle, J., He, T.C., Yuan, C.S. and Du, W. 2011. Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53. Cancer Lett. 301: 185-192.
  2. Yu, L.F., Lu, W.G., Xiang, P., Wang, L.L., Chen, L., Chen, T.T., Gu, M.M., Wang, C.Z. and Yuan, C.S. 2011. Enhancing oral bioavailability of methylnaltrexone using an emulsion formulation. Lett. Drug Des. Discov. 8: 87-92.
  3. Wang, C.Z. and Yuan, C.S. 2011. Panax quinquefolius (American ginseng) and Panax notoginseng (notoginseng) in cancer chemoprevention. In: Evidence-based Anticancer Materia Medica (Cho, W.C.S. ed.) Springer: New York. p. 97-109.
  4. Wang, C.Z. and Yuan, C.S. 2011. Chemopreventive properties of ginseng compounds on colon cancer. In: Bioactrive Foods and Extracts: Cancer Treatment and Prevention (Watson, R.R. and Preedy V.R. eds.) CRC Press: New York. p. 393-401.
  5. Sun, S., Qi, L.W., Du, G.J., Mehendale, S.R., Wang, C.Z. and Yuan, C.S. 2011. Red notoginseng: higher ginsenoside content and stronger anticancer potential than Asian and American ginseng. Food Chem. 125: 1299–1305.
  6. Du, G.J., Dai, Q., Wlliams, S., Wang, C.Z. and Yuan, C.S. 2011. Synthesis of protopanaxadiol derivatives and evaluation of their anticancer activities. Anticancer Drugs 22: 35-45.
  7. He, B.C., Gao, J.L., Luo, X., Luo, J., Shen, J., Wang, L., Zhou, Q., Wang, Y.T., Luu, H.H., Haydon, R.C., Wang, C.Z., Du, W., Yuan, C.S., He, T.C., Zhang, B.Q. 2011. Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ß-catenin signaling. Int. J. Oncol. 38: 437-445.
  8. Yuan, C.S. and Tanaka, H. 2011. Bioactivity of American ginseng by knockout extract preparation using monoclonal antibody. Curr. Drug Discov. Technol. 8: 32-41.
  9. Rotshteyn, Y., Boyd, T.A. and Yuan, C.S. 2011. Methylnaltrexone bromide: Research update of pharmacokinetics following parenteral administration. Expert Opin. Drug Metab. Toxicol. 7: 227-235.
  10. Qi, L.W., Wang, C.Z. and Yuan C.S. 2011. Isolation and analysis of ginseng: advances and challenges. Nat. Prod. Rep. 28: 467-495.
  11. Xie, J.T., Du, G.J., McEntee, E., Aung, H.H., He, H., Mehendale, S.R., Wang, C.Z. and Yuan, C.S. 2011. Effects of triterpenoid glycosides from fresh ginseng berry on SW480 human colorectal cancer cell line. Cancer. Res. Treat. 43: 49-55.
  12. Qi, L.W., Wang, C.Z. and Yuan C.S. 2011. Ginsenosides from American ginseng: Chemical and pharmacological diversity. Phytochemistry 72: 689-699.
  13. Huang, W.H., Zhang, Q.W., Meng, L.Z., Yuan, C.S., Wang, C.Z. and Li, S.P. 2011. Oplopanphesides A-C, three new phenolic glycosides from the root barks of Oplopanax horridus. Chem. Pharm. Bull. 59: 676-679.
  14. Sun, S., Qi, L.W., Du, G.J., Mehendale, S.R., Wang, C.Z. and Yuan, C.S. 2011. Red notoginseng: higher ginsenoside content and stronger anticancer potential than Asian and American ginseng. Food Chem. 125: 1299–1305.
  15. Wang, C.Z. and Yuan, C.S. 2011. Panax quinquefolius. (American ginseng) and Panax notoginseng. (notoginseng) in cancer chemoprevention. In: Evidence-based Anticancer Materia Medica. (Cho, W.C.S. ed.) Springer: New York. p. 97-109.
  16. Dougherty, U., Mustafi, R., Wang, Y., Musch, M.W., Wang, C.Z., Konda, V.J., Kulkarni, A., Hart, J., Dawson, G., Kim, K.E., Yuan, C.S., Chang, E.B. and Bissonnette, M. 2011. American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR. BMC Complement. Altern. Med. 11: 111-121.
  17. Wang, C.Z., Mehendale, S.R., Calway, T. and Yuan, C.S. 2011. Botanical flavonoids on coronary heart disease. Am. J. Chin. Med. . 39: 661-671. Chang, W.T., Li, J., Huang, H.H., Liu, H., Han, M., Ramachandran, S., Li, C.Q., Sharp, W.W., Hamann, K.J., Yuan, C.S., Vanden Hoek, T.L. and Shao, Z.H. 2011. Baicalein protects against doxorubicin-induced cardiotoxicity by attenuation of mitochondrial oxidant injury and JNK activation. J. Cell Biochem. 112: 2873-2881.
  18. Wang, H.Y., Qi, L.W., Wang, C.Z. and Li, P. 2011. Bioactivity enhancement of herbal supplements by intestinal microbiota focusing on ginsenosides. Am. J. Chin. Med. 39: 1103-1115.
  19. Qi, L.W., Wang, C.Z., Du, G.J., Zhang, Z.Y., Calway, T. and Yuan, C.S. 2011. Metabolism of ginseng and its interactions with drugs. Curr. Drug Metab. 12: 818-822.
  20. Wang, C.Z., Kim, K.E., Du, G.J., Qi, L.W., Wen, X.D., Li, P., Bauer, B.A., Bissonnette, M.B., Musch, M.W., Chang, E.B. and Yuan, C.S. 2011. Ultra-performance liquid chromatography and time-of-flight mass spectrometry analysis of ginsenoside metabolites in human plasma. Am. J. Chin. Med. 39: 1161-1171.
  21. Wang, C.Z., Du, G.J., Zhen, Z., Calway, T. and Yuan, C.S. 2011. Significant dose differences in donepezil purchased from the United States and Canada. Ann. Intern. Med. 155: 279-280.

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2010

  1. Li, B., Wang, C.Z., He, T.C., Yuan, C.S. and Du, W. 2010. Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells. Cancer Lett. 289: 62-70.
  2. Morinaga, O., Uto, T., Yuan, C.S., Tanaka, H. and Shoyama, Y. 2010. Evaluation of a new eastern blotting technique for the analysis of ginsenoside Re in American ginseng berry pulp extracts. Fitoterapia 81: 284-288.
  3. Rodriguez, M., Du, G.J., Wang, C.Z. and Yuan, C.S. 2010. Panaxadiol's anticancer activity is enhanced by epicatechin. Am. J. Chin. Med. 38: 1233-1235.
  4. Yuan, C.S., Wang, C.Z., Wicks, S.M. and Qi, L.W. 2010. Chemical and pharmacological studies of saponins with a focus on American ginseng. J. Ginseng Res. 34: 160-167.
  5. Wang, C.Z. and Yuan, C.S. 2010. Ginseng, American (Panax quinquefolius). In: Encyclopedia of Dietary Supplements, 2nd Edition (Coates, P.M., Betz, J.M., Blackman, M.R., Cragg, G.M., Levine, M., Moss, J. and White, J.D. eds.) Informa Healthcare: New York, NY. p. 339-347.
  6. Qi, L.W., Wang. C.Z. and Yuan CS. 2010. American ginseng: potential structure-function relationship in cancer chemoprevention. Biochem. Pharmacol. 80: 947-954.
  7. Yuan, C.S. and Qi, L.W. 2010. Pharmacological effects of ginseng. In: Advances in Ginseng Research 2010 (Yang, D.C., Kim, S.K. and Oh, H.I. eds.) Korea Soc. Ginseng: Seoul. p. 95-107.
  8. Sun, S., Wang, C.Z., Tong, R., Li., X.L., Fishbein, A., Wang, Q., He, T.C., Du, W. and Yuan, C.S. 2010. Effects of steaming the root of Panax notoginseng/ on chemical composition and anticancer activities. Food Chem. 118: 307-314.
  9. Wang, C.Z., Aung, H.H., Mehendale, S.R., Shoyama, Y. and Yuan, C.S. 2010. High performance liquid chromatographic analysis and anticancer potential of Oplopanax horridus: Comparison of stem and berry extracts. Fitoterapia 81: 132-139.
  10. Sun, S., Li., X.L., Wang, C.Z., Williams, S. and Yuan, C.S. 2010. Improving anticancer activities of Oplopanax horridus root bark extract by removing water-soluble components. Phytother. Res. 24: 1166-1174.
  11. Sun, S., Du, G.J., Qi, L.W., Williams, S., Wang, C.Z. and Yuan, C.S. 2010. Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.). J. Ethnopharmacol. 132: 280-285.
  12. Li., X.L., Sun, S., Du, G.J., Qi, L.W., Williams, S., Wang, C.Z. and Yuan, C.S. 2010. Effects of Oplopanax horridus on human colorectal cancer cells. Anticancer Res. 30: 295-302.
  13. Huang, W.H., Zhang, Q.W., Wang, C.Z., Yuan, C.S. and Li, S.P. 2010. Isolation and identification of two new polyynes from a North American ethnic medicinal plant - Oplopanax horridus (Smith) Miq. Molecules 15: 1089-1096.
  14. Huang, W., Yang, J., Zhao, J., Wang, C.Z., Yuan, C.S. and Li, S.P. 2010. Quantitative analysis of six polyynes and one polyene in Oplopanax horridus and Oplopanax elatus by pressurized liquid extraction and on-line SPE-HPLC. J. Pharm. Biomed. Anal. 53: 906-910.
  15. Wang, C.Z., Li., X.L., Wang, Q.F., Mehendale, S.R. and Yuan, C.S. 2010. Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells. Phytomedicine 17: 63-68.
  16. Ang-Lee, M.K., Yuan, C.S. and Moss, J. 2010. Complementary and alternative therapies. In: Miller's Anesthesia, 7th Edition, (Miller, R.D. ed.) Churchill Livingstone Elsevier: Philadelphia. p. 957-966.
  17. Horlocker, T.T., Wedel, D.J., Rowlingson, J.C., Enneking, F.K., Kopp, S.L., Benzon, H.T., Brown, D.L., Heit, J.A., Mulroy, M,F., Rosenquist, R.W., Tryba, M. and Yuan C.S. 2010. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines. Reg. Anesth. Pain Med. 35: 64-101.

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2009

  1. Wang, C.Z., Xie, J.T., Fishbein, A., Aung, H.H., He, H., Mehendale, S.R., He, T.C., Du, W. and Yuan, C.S. 2009. Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells. Phytother. Res. 23: 6-13.
  2. Wang, C.Z., Li, X.L., Wang, Q.F., Mehendale, S.R., Fishbein, A.B., Han, A.H., Sun, S. and Yuan, C.S. 2009. The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW-480 colon cancer cells. Oncol. Rep. 21: 577-584.
  3. Sun, X.Y., Zheng, Y.P., Lin, D.H., Zhang, H., Zhao, F, and Yuan, C.S. 2009. Potential anti-cancer activities of furanodiene, a sesquiterpene from Curcuma wenyujin. Am. J. Chin. Med. 37: 589-596.
  4. Li., X.L., Wang, C.Z., Mehendale, S.R., Sun, S., Wang, Q. and Yuan, C.S. 2009. Panaxadiol, a purified ginseng component, enhances the anti-cancer effects of 5-fluorouracil in human colorectal cancer cells. Cancer Chemother. Pharmacol. 64: 1097-1104.
  5. Fishbein, A.B., Wang, C.Z., Li., X.L., Mehendale, S.R., Sun, S., Aung, H.H. and Yuan, C.S. 2009. Asian ginseng enhances 5-fluoruracil's anti-proliferative effects on human colorectal cancer: Comparison between white and red ginseng. Arch. Pharm. Res. 32: 505-513.
  6. Xie, J.T., Wang, C.Z., Zhang, B., Mehendale, S.R., Li, X.L., Sun, S. Aung, H.H., Du, W., He, T.C. and Yuan, C.S. 2009. In vitro and in vivo anticancer effects of American ginseng berry: Exploring representative compounds. Biol. Pharm. Bull. 32: 1552-1558.
  7. Li., X.L., Wang, C.Z., Sun, S., Mehendale, S.R., Du, W., He, T.C. and Yuan, C.S. 2009. American ginseng berry enhances chemopreventive effect of 5-FU on human colorectal cancer cells. Oncol. Rep. 22: 943-952.
  8. Yuan, C.S., Wang, C.Z., Mehendale, S.R., Aung, H.H., Foo, A. and Israel RJ. 2009. Protease inhibitor-induced nausea and vomiting is attenuated by a peripherally acting, opioid-receptor antagonist in a rat model. AIDS Res. Ther. 6:19.
  9. Shao, Z.H., Wojcik, K.R., Dossumbekova, A., Hsu, C., Mehendale, S.R., Li, C.Q., Qin, Y., Sharp, W.W., Chang, W.T., Hamann, K.J., Yuan, C.S. and Vanden Hoek TL. 2009. Grape seed proanthocyanidins protect cardiomyocytes from ischemia and reperfusion injury via Akt-NOS signaling. J. Cell Biochem. 107: 697-705.
  10. Tong, R., Mehendale, S.R., Wang, C.Z., Shao, Z.H. and Yuan, C.S. 2009. Comparison of antioxidant effects of various Scutellaria baicalensis fractions and the potential role of the upregulation of catalase. Am. J. Chin. Med. 37: 621-623.
  11. Xie, J.T., Wang, C.Z., Ni, M., Fishbein, A. and Yuan, C.S. 2009. Anti-diabetic effect of American ginseng may not be linked to antioxidant activity: Comparison between American ginseng and Scutellaria baicalensi using an ob/ob mice model. Fitoterapia 80: 306-311.
  12. Wang, C.Z., Ni, M., Sun, S., Li., X.L., He, H., Mehendale, S.R. anåd Yuan, C.S. 2009. Detection of adulteration of notoginseng root extract with other Panax species by quantitative HPLC coupled with PCA. J. Agric. Food Chem. 57: 2363-2367.
  13. Mehendale, R.S. and Yuan, C.S. 2009. Gastrointestinal dysfunction with opioid use. In: Current Therapy in Pain (Smith, H.S. ed.) Saunders / Elsevier: New York. p. 424-428.
  14. Yuan, C.S. and Israel, R.J. 2009. Methylnaltrexone: A peripherally acting opioid antagonist. In: Opiate Receptors and Antagonists (Dean, R. et al., eds.) Humana Press: New York. p. 175-198.
  15. Yuan, C.S., Foss, J.F., Williams, W.A. and Moss, J. 2009. Development and use of methylnaltrexone, a peripherally acting opioid antagonist, to treat side effects related to opioid use. Drug Dev. Res. 70: 403–416.
  16. Wang, C.Z., Li., X.L., Sun, S., Xie, J.T., Aung, H.H., Tong, R., McEntee, E. and Yuan, C.S. 2009. Methylnaltrexone, a peripherally acting opioid receptor antagonist, enhances tumoricidal effects of 5-FU on human carcinoma cells. Anticancer Res. 29: 2927-2932.
  17. Yuan, C.S., Wang, C. Z., Attele, A. and Zhang, L. 2009. Methylnaltrexone reduced body weight gain in ob/ob mice. J. Opioid Manag. 5: 213-218.
  18. Yuan, C.S., Sun, S., Attele, A., Wang, C.Z., Tong, R.T. and Israel, R.J. 2010. Methylnaltrexone potentiates body weight and fat reduction with leptin. J. Opioid Manag. 5: 373-378.

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2008

  1. Luo, X., Wang, C.Z., Chen, J., Song, W.X., Luo, J., Tang, N., He, B.C., Kang, Q., Wang, Y., Du, W., He, T.C. and Yuan, C.S. 2008. Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells. Int. J. Oncol. 32: 975-983.
  2. Andrade, A.S., Hendrix, C., Parsons, T.L., Caballero, B., Yuan, C.S., Flexner, C.W., Dobs, A.S. and Brown, T.T. 2008. Pharmacokinetic and metabolic effects of American ginseng (Panax quinquefolius) in healthy volunteers receiving the HIV protease inhibitor indinavir. BMC Complement. Altern. Med. 8: 50 (1-10).
  3. Mehendale, R.S. and Yuan, C.S. 2008. Gastrointestinal dysfunction with opioid use. In: Current Therapy in Pain (Smith, H.S. ed.) Elsevier / Saunders: New York. p. 422-426.
  4. Woo, M., O'Connor, M.F., Yuan, C.S. and Moss, J. 2008. Reversal of opioid-induced gastric dysfunction in a critically ill burn patient after methylnaltrexone. Anesth. Analg. 107: 1965-1967.
  5. Yuan, C.S. 2008. Ginseng pharmacology investigation. Proc. Int. Ginseng Conf. p. 77-84.
  6. Wang, C.Z., Li, X.L., Wang, Q.F., Mehendale, S.R., Fishbein, A.B., Aung, H.H., Sun, S. and Yuan, C.S. 2008. Effects of steamed American ginseng extracts on apoptotic pathways in human colorectal cancer cells. Proc. Int. Ginseng Conf. p. 101-114.
  7. Lin, E., Wang, Y., Mehendale, S., Sun, S., Wang, C.Z., Xie, J.T., Aung, H.H. and Yuan, C.S. 2008. Antioxidant protection by American ginseng in pancreatic ß-cells. Am. J. Chin. Med. 36: 981-988.
  8. Mehendale, R.S. and Yuan, C.S. 2008. Clinical pharmacology of opioids: Basic pharmacology. In: Cancer Pain, 2nd Edition (Sykes, N., Bennett, M. and Yuan, C.S., eds.) Arnold: London. p. 151-167.
  9. Wang, C.Z. and Yuan, C.S. 2008. Potential role of ginseng in the treatment of colorectal cancer. Am. J. Chin. Med. 36: 1019-1028.
  10. Wang, C.Z., Aung, H.H., Zhang, B., Sun, S., Li, X.L., He, H., Xie, J.T., He, T.C., Du, W. and Yuan, C.S. 2008. Chemopreventive effects of heat-processed Panax quinquefolius root on human breast cancer cells. Anticancer Res. 28: 2545-2551.

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2007

  1. Aung, H.H., Mehendale, S.R., Wang, C.Z., Xie, J.T., McEntee, E. and Yuan, C.S.  2007.  Cisplatin’s tumoricidal effect on human breast carcinoma MCF-7 cells was not attenuated by American ginseng. Cancer Chemother. Pharmacol. 59: 369-374.
  2. Wang, C.Z., Li, P., Ding, J.Y., Peng, X. and Yuan, C.S.  2007.  Simultaneous identification of Bulbus Fritillariae cirrhosae using PCR- RFLP analysis.Phytomedicine 14: 628-632.
  3. Wang, C.Z., Li, P., Ding, J.Y., Fishbein, A. and Yuan, C.S.  2007.  Discrimination of Lonicera japonica Thunb. from different geographical origins using restriction fragment length polymorphism analysis.  Biol. Pharm. Bull. 30: 779-782.
  4. Wang, C.Z., Luo, X., Zhang, B., Song, W.X., Han, A.H., Xie, J.T., He, C.T. and Yuan, C.S.  2007.  Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells.  Cancer Chemother. Pharmacol.  60: 69-79.
  5. Xie, J.T., Wicks, S., McEntee, E. and Yuan, C.S.  2007.  American ginseng and Asian ginseng reduce blood glucose level and body weight. Phytopharmacol. Ther. Values 2: 111-123.
  6. Wicks, SM., Tong, R., Wang, C.Z., O'connor, M., Karrison, T., Li, S., Moss, J. and Yuan CS.  2007.  Safety and tolerability of ganoderma lucidum in healthy subjects: A double-blind randomized placebo-controlled trial.  Am. J. Chin. Med. 35: 407-414.
  7. Chang, W.T., Shao, Z.H., Yin, J.J., Mehendale, S.R., Wang, C.Z., Li, J., Chen, W.J., Chien, C.T., Becker, L.B., Vanden Hoek, T. L. and Yuan, C.S.  2007.  Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes.  Eur. J. Pharmacol. 566: 58-66.
  8. Yuan, C.S.  2007.  Methylnaltrexone mechanisms of action and effects on opioid bowel dysfunction and other opioid adverse effects.  Ann. Pharmacother. 41: 984-993.
  9. Wang, C.Z. and Yuan, C.S.  2007.  Analysis and active constituents of Panax notoginseng. In: Analysis of Natural Glycosides (Shoyama, Y. ed.)  Research Signpost: Kerala. p. 1-15.
  10. Wang, C.Z., Aung, H.H., Ni, M., Wu, J.A., Tong, R., Wicks, S., He, T.C. and Yuan, C.S.  2007.  Red American ginseng: Ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots.  Planta Med. 73: 669-674.
  11. Wang, C.Z., Mehendale, S.R. and Yuan, C.S.  2007.  Commonly used antioxidant botanicals: Active constituents and their potential role in cardiovascular illness. Am. J. Chin. Med.35: 543-558.
  12. Xie, J.T., Wang, C.Z., Ni, M., Wu, J.A., Mehendale, S.R., Aung, H.H., Foo, A. and Yuan, C.S.  2007.  American ginseng berry juice intake reduces blood glucose and body weight in ob/ob mice.  J. Food Sci.  72: 590-594.
  13. Aung, H.H., Wang, C.Z., Ni, M., Fishbein, A., Mehendale, S.R., Xie, J.T., Shoyama, Y. and Yuan, C.S.  2007.  Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells.  Exp. Oncol. 29: 175-180.
  14. Wang, C.Z., Xie, J.T., Zhang, B., Ni, M., Fishbein, A., Aung, H.H., Mehendale, S.R., Du, W., He, T.C. and Yuan, C.S.  2007.  Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells.  Int. J. Oncol.  31: 1149-1156.
  15. Mehendale, S., Aung, H., Wang, C.Z., Tong, R., Foo, A., Xie, J.T. and Yuan, C.S.  2007.  Scutellaria baicalensis and a constituent flavonoid, baicalein, attenuate ritonavir-induced gastrointestinal side-effects.  J. Pharm. Pharmacol.  59: 1567-1572.

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2006

  1. Mehendale, S.R. and Yuan, C.S.  2006.  Opioid-induced gastrointestinal dysfunction.  Dig. Dis.  24: 105-112.
  2. Xie, J.T., Chang, W.T., Wang, C.Z., Mehendale, R.S., Li J., Ambihaipahar, R., Ambihaipahar, U., Fong, H.H. and Yuan, C.S.  2006.  Curry leaf (Murraya koenigii Spreng.) reduces blood cholesterol and glucose levels in ob/obmice.  Am. J. Chin. Med. 34: 279-284.
  3. Xie, J.T., Shao, Z.H., Vanden Hoek, T.L., Chang, W.T., Li, J., Mehendale, S., Wang, C.Z., Hsu, C.W., Becker, L.B., Yin, J.J. and Yuan, C.S.  2006.  Antioxidant effects of ginsenoside Re in cardiomyocytes.  Eur. J. Pharmacol.532: 201-207.
  4. Wang, C.Z., McEntee, E., Wicks, S., Wu, J.A. and Yuan, C.S.  2006.  Phytochemical and analytical studies of Panax notoginseng (Burk.) F.H. Chen.  J. Nat. Med. 60: 97-106.
  5. Chang, W.T., Shao, Z.H., Vanden Hoek, T. L., McEntee, E., Mehendale, S.R., Li, J., Becker, L.B. and Yuan, C.S.  2006.  Cardioprotective effects of grape seed proanthocyanidins, baicalin and wogonin: Comparison between acute and chronic treatments.  Am. J. Chin. Med. 34: 363-365.
  6. Wang, C.Z., Wu, J.A., McEntee E. and Yuan, C.S.  2006.  Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatography.  J. Agric. Food Chem. 54: 2261-2266.
  7. Xie, J.T., Wang, C.Z., Wicks, S., Yin, J.J., Kong, J., Li, J., Li, Y.C. and Yuan, C.S.  2006.  Ganoderma lucidum inhibits proliferation of SW 480 human colorectal cancer cells.  Exp. Oncol. 28: 25-29.
  8. Yuan, C.S. and Israel, R.J.  2006.  Methylnaltrexone, a novel peripheral opioid receptor antagonist for the treatment of opioid side effects.  Expert Opin. Investig. Drugs 15: 541-552.
  9. Bauer, B.A., Ang-Lee, M.K., Bieber, E.J. and Yuan, C.S.  2006.  Prevalence and impact of complementary and alternative medicine on conventional medicine.  In: Textbook of Complementary and Alternative Medicine, 2nd Edition (Yuan, C.S., Bieber, E.J. and Bauer, B.A., eds.) Informa Healthcare: New York. p. 3-6.
  10. Xie, J.T., Attele, A.S. and Yuan, C.S.  2006.  Ginseng: beneficial and potential adverse effects.  In: Textbook of Complementary and Alternative Medicine, 2nd Edition (Yuan, C.S., Bieber, E.J. and Bauer, B.A., eds.) Informa Healthcare: New York. p. 71-89.
  11. Mehendale, S.R., Bauer, B.A. and Yuan, C.S.   2006.  Risks of ephedra-containing supplements.  In: Textbook of Complementary and Alternative Medicine, 2nd Edition (Yuan, C.S., Bieber, E.J. and Bauer, B.A., eds.) Informa Healthcare: New York. p. 123-128.
  12. Mehendale, S.R., Aung, H.H. and Yuan, C.S.   2006.  Chemotherapy-induced nausea and vomiting. In: Textbook of Complementary and Alternative Medicine, 2nd Edition (Yuan, C.S., Bieber, E.J. and Bauer, B.A., eds.) Informa Healthcare: New York. p. 655-659.
  13. Wu, J.A. and Yuan, C.S.  2006.  Boost AIDS patients’ immune systems.  In:Textbook of Complementary and Alternative Medicine, 2nd Edition (Yuan, C.S., Bieber, E.J. and Bauer, B.A., eds.) Informa Healthcare: New York. p. 671-681.
  14. Ang-Lee, M.K, Moss, J. and Yuan, C.S.  2006.  Herbal medicines and perioperative care.  Anesthesiology 105: 441-442.
  15. Xie, J.T., Aung, H.H., Wang, C.Z., Mehendale, S.R., McEntee, E., Wicks, S., Li, J., and Yuan, C.S.  2006.  Effects of Panax notoginseng, ginsenoside Rb1, and notoginsenoside R1 on proliferation of human breast carcinoma MCF-7 cells.  Orient. Pharm. Exp. Med. 4: 286-292.
  16. Mehendale, S.R., Wang, C.Z. Shan, Z.H. Li, C.Q., Xie, J.T., Aung, H. and Yuan, C.S.  2006.  Chronic treatment with American ginseng berry and its polyphenolic constituents attenuate oxidant stress in cardiomyocytes.  Eur. J. Pharmacol. 553: 209-214.
  17. Wang, C.Z., Zhang, B., Ni, M., Wang, A., Lou, X., Song, W.X., Han, A.H., Xie, J.T., Tong, R., He, T.C. and Yuan, C.S.  2006.  Steamed American ginseng berry: Ginsenoside analyses and anti-cancer activities. J. Agric. Food Chem.54: 9936-9942.

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2005

  1. Wang, C.Z., Li, P., Ding, J.Y., Jin, G.Q. and Yuan, C.S.  2005.  Identification ofFritillaria pallidiflora using diagnostic PCR and PCR-RFLP based on nuclear ribosomal DNA internal transcribed spacer sequences.  Planta Medica 71: 384-386.
  2. Yuan, C.S., Doshan, H., Charney, M.R., O’Connor, M., Karrison, T., Maleckar, S.A., Israel, R. and Moss, J.  2005.  Tolerability, gut effect, and pharmacokinetics of methylnaltrexone following repeated intravenous administration in humans.  J. Clin. Pharmacol. 45: 538-546.
  3. Wang, A., Wang, C.Z., Wu, J.A., Osinski, J. and Yuan, C.S.  2005.  Determination of major ginsenosides in Panax quinquefolius (American ginseng) using high-performance liquid chromatography.  Phytochem. Anal.16:272-277.
  4. Ang-Lee, M.K., Yuan, C.S. and Moss, J.  2005.  Complementary and alternative therapies. In: Miller’s Anesthesia, 6th Edition, (Miller, R.D. ed.) Elsevier Churchill Livingstone: Philadelphia. p. 605-616.
  5. Xie, J.T., Mehendale, S.R., Li, X., Quigg, R., Wang, X., Wang, C.Z., Wu, J.A., Aung, H.H., Rue, P.A., Bell, G.I.  and Yuan, C.S.  2005.  Anti-diabetic effect of ginsenoside Re in ob/ob mice.  Biochim. Biophys. Acta. 10;1740: 319-325.
  6. Xie, J.T., Mehendale, S. and Yuan, C.S.  2005. Ginseng and Diabetes.  Am. J. Chin. Med. 33: 397-404.
  7. Yuan, C.S.  2005.  Effects of ginseng on warfarin.  J. Resp. Dis. 26: 96-97.
  8. Mehendale, S., Aung, H.H., Wang, A., Yin, J.J., Wang C.Z., Xie, J.T. and Yuan, C.S.  2005.  American ginseng berry extract and ginsenoside Re attenuate cisplatin-induced kaolin intake in rats.  Cancer Chemother. Pharmacol. 56: 63-69.
  9. Yuan, C.S. and Pappagallo, M.  2005. Opioid bowel dysfunction. In:Handbook of Opioid Bowel Syndrome (Yuan, C.S. ed.) Haworth Medical Press: New York. p. 1-4.
  10. Mehendale, S.R. and Yuan, C.S.  2005.  Pathophysiology of opioid induced bowel dysfunction. In: Handbook of Opioid Bowel Syndrome (Yuan, C.S. ed.) Haworth Medical Press: New York. P. 29-43.
  11. Wei, G., Moss, J. and Yuan, C.S.  2005.  Opioid induced immunosuppression. In: Handbook of Opioid Bowel Syndrome (Yuan, C.S. ed.) Haworth Medical Press: New York. p. 45-57.
  12. Boyd, T.A. and Yuan, C.S.  2005.  Methylnaltrexone: Investigation in treating opioid bowel dysfunction. In: Handbook of Opioid Bowel Syndrome (Yuan, C.S. ed.) Haworth Medical Press: New York. p. 197-221.
  13. Xie, J.T., Wang, C.Z., Kim, S. and Yuan, C.S.  2005.  The anti-hyperglycemic property of different ginseng partitions.  Orient. Pharm. Exp. Med.  5: 1-15.
  14. Xie, J.T., Wang, C.Z., Wang, A., Wu, J., Basila, D. and Yuan, C.S.  2005.  Antihyperglycemic effects of total ginsenosides from leaf and stem of Panaxginseng.  Acta Pharmacol. Sin. 26: 1104-1110.
  15. Wang, C.Z., Fishbein, A., Aung, H.H., Mehendale, S.R., Chang, W.T., Xie, J.T., Li, J. and Yuan, C.S.  2005.  Polyphenol contents in grape seed extracts correlate with antipica effects in cisplatin treated rats.  J. Altern. Complement. Med. 11: 1059-1065.
  16. Wang, C.Z., Basila, D., Aung, H.H., Mehendale, S.R., Chang, W.T., McEntee, E., Guan, X. and Yuan, C.S.  2005.  Effects of Ganoderma lucidum extract on chemotherapy-induced nausea and vomiting in a rat model.  Am. J. Chin. Med. 33: 807-815.
  17. Wang, A., Foss, J., Yuan, C.S. and Osinski, J.  2005.  Separation and determination of methylnaltrexone in human plasma samples after oral administration by HPLC coupled with electrochemical detection.  Chem. Res. Chin. U.  21: 268-273.
  18. Aung, H.H., Mehendale, S.R., Wang, C.Z., Xie, J.T., Chang, W.T. and Yuan, C.S.  2005.  Scutellaria baicalensis decreases ritonavir-induced nausea. AIDS Res. Ther. 2:12.

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2004

  1. Xie, J.T., Mehendale, S.R., Wang, A., Aung, H.H., Wu, J.A., Osinski, J. and Yuan, C.S.  2004.  American ginseng leaf: Ginsenoside analysis and hypoglycemic activity.  Pharmacol. Res.  49: 113-117.
  2. Xie, J.T., Wu, J.A., Mehendale, S., Aung, H.H. and Yuan, C.S.  2004.  Anti-hyperglycemic effect of polysaccharides fraction from American ginseng berry extract in ob/ob mice.  Phytomedicine 11: 182-187.
  3. Mehendale, S., Xie, J.T., Aung, H.H., Guan X. and Yuan, C.S.  2004.  Nucleus accumbens receives gastric vagal inputs.  Acta Pharmacol. Sin. 25: 271-275.
  4. Horlocker, T.T., Wedel, D.J., Benzon, H., Brown, D.L., Enneking, F.K., Heit, J.A., Mulroy, M.F., Rosenquist, R.W., Rowlingson, J., Tryba, M. and Yuan C.S.  2004.  Regional anesthesia in the anticoagulated patient: Defining the risks.  Reg. Anesth. Pain. Med. 29(S1): 1-11.
  5. Aung, H.H., Mehendale, S., Xie, J.T., Moss, J. and Yuan, C.S.  2004.  Methylnaltrexone prevents morphine-induced kaolin intake in the rat.  Life Sci.  74: 2685-2691.
  6. Shao, Z.H., Xie. J.T., Vanden Hoek, T.L., Mehendale, S., Aung, H., Li, C.Q., Qin, Y., Schumacker, P.T., Becker, L.B. and Yuan, C.S.  2004.  Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stress.  Biochim. Biophys. Acta. 24;1670: 165-171.
  7. Yuan, C.S., Mehendale, S., Xiao, Y., Aung, H.H., Xie, J.T. and Ang-Lee, M.K.  2004.  The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activities.  Anesth. Analg. 98: 353-538.
  8. Xie, J.T., Wu, J.A., Lin, E., Wang, C.Z. and Yuan, C.S.  2004.  Constituents and effects of ginseng leaf.  Orient. Pharm. Exp. Med. 4: 1-8.
  9. Mehendale, R.S., Bauer, B. and Yuan, C.S.  2004.  Ephedra-containing dietary supplements in the U.S. versus ephedra as a Chinese medicine. Am. J. Chin. Med.  32: 1-10.
  10. Shao, Z.H., Vanden Hoek, T.L., Li, C.Q., Schumacker, P.T., Becker, LB., Chan, K.C., Qin, Y., Yin, J.J. and Yuan, C.S.  2004.  Synergistic effect ofScutellaria baicalensis and grape seed proanthocyanidins on scavenging hydroxyl radicals in vitro.  Am. J. Chin. Med.  32: 89-95.
  11. Kim, J.S., Tanaka, H., Yuan, C.S., and Shoyama, Y.  2004.  Development of monoclonal antibody against isoquinoline alkaloid coptisine and its application for the screening of medicinal plants.  Cytotechnology 44: 115-123.
  12. Wang, C.Z. Osinski, J., Shao, Z.H., Basila, D., Kim, S. and Yuan, C.S.  2004.  Determination of polyphenolic compounds in grape seed extracts using reverse-phase high performance liquid chromatography.  Orient. Pharm. Exp. Med. 4: 267-273.
  13. Aung, H.H., Dey, L. Rand, V. and Yuan, C.S.  2004.  Alternative therapies for male and female sexual dysfunction. Am. J. Chin. Med. 32: 161-173.
  14. Yuan, C.S.  2004.  Clinical status of methylnaltrexone, a new agent to prevent and manage opioid-induced side effects.  J. Support. Oncol.  2: 111-117 (Discussion 119-122).
  15. Mehendale, R.S., Aung, H.H., Yin, J.J., Lin, E., Fishbein, A., Wang, C.Z., Xie, J.T. and Yuan, C.S.  2004.  Effects of antioxidant herbs on chemotherapy-induced nausea and vomiting in a rat-pica model.  Am. J. Chin. Med. 32: 897-905.
  16. Yuan, C.S., Mehendale, R.S., Wang, C.Z., Jiang, T., Guan, X. and Shoyama, Y.  2004.  Effects of Corydalis yanhusuo and Angelicae dahuricae on cold pressor-induced pain in humans: A controlled trial.  J. Clin. Pharmacol. 44: 1323-1327.
  17. Yuan, C.S., Wei, G., Dey, L., Karrison, T., Nahlik, L., Maleckar, S.A., Kasza, K., Ang-Lee, M.K. and Moss, J.  2004.  American ginseng reduces warfarin’s effect in healthy patients: A randomized controlled trial.  Ann. Intern. Med.141: 23-27.

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2003

  1. Aung, H.H., Dey, L., Mehendale, S., Xie, J.T., Wu, J.A. and Yuan, C.S.  2003.  Scutellaria baicalensis extract decreases cisplatin-induced pica in rats. Cancer Chemother. Pharmacol. 52: 453-458.
  2. Wei, G., Moss, J. and Yuan, C.S.  2003.  Opioid-induced immunosuppression: Is this a centrally-mediated or peripherally-mediated mechanism? Biochem. Pharmacol. 65: 1761-1766.
  3. Ho, W.Z., Guo, C..J., Yuan, C.S., Douglas, S.D. and Moss, J.  2003.  Methylnaltrexone antagonizes opioid-mediated enhancement of HIV infection of human blood mononuclear phagocytes.  J. Pharmacol. Exp. Ther. 307:1158-1162.
  4. Horlocker, T.T., Wedel, D.J., Benzon, H., Brown, D.L., Enneking, F.K., Heit, J.A., Mulroy, M.F., Rosenquist, R.W., Rowlingson, J., Tryba, M. and Yuan C.S.  2003.  Regional anesthesia in the anticoagulated patient: Defining the risks.  Reg. Anesth. Pain. Med. 28: 172-197.
  5. Long, J., Yuan, M.J., Whinston, A.B. and Yuan, C.S.  2003.  Use wireless web services to improve patient compliance in clinical drug trials. Int. J. Healthcare Technol. Manag. 5: 394-406.
  6. Yuan, C.S., Bieber, E.J. and Ang-Lee, M.K.  2003.  Complementary and alternative medicine: Prevalence and impact on conventional medicine.  In:Textbook of Complementary and Alternative Medicine (Yuan, C.S. and Bieber, E.J. eds.) Parthenon: New York. p. 3-4.
  7. Dey, L. and Yuan, C.S.  2003.  Other commonly used herbs.  In: Textbook of Complementary and Alternative Medicine (Yuan, C.S. and Bieber, E.J. eds.) Parthenon: New York. p. 33-35.
  8. Dey, L., Attele, A.S. and Yuan, C.S.  2003.  Are there any remedies for obesity?  In: Textbook of Complementary and Alternative Medicine (Yuan, C.S. and Bieber, E.J. eds.) Parthenon: New York. p. 279-287.
  9. Aung, H.H., Dey, L. and Yuan, C.S.  2003.  Warning: Adverse effects of ephedra-containing dietary supplements.  In: Textbook of Complementary and Alternative Medicine (Yuan, C.S. and Bieber, E.J. eds.) Parthenon: New York. p. 289-297.
  10. Wu, J.A. and Yuan, C.S.  2003.  Availability of medicinal herbs to boost HIV patients’ immune systems.  In: Textbook of Complementary and Alternative Medicine (Yuan, C.S. and Bieber, E.J. eds.) Parthenon: New York. p. 347-353.
  11. Ang-Lee, M.K., Moss, J. and Yuan, C.S.  2003.  What you and your patients should know before surgery.  In: Textbook of Complementary and Alternative Medicine (Yuan, C.S. and Bieber, E.J. eds.) Parthenon: New York. p. 385-396.
  12. Attele, A.S., Guan, X., Dey, L., Maleckar, S.A. and Yuan, C.S.  2003.  Analgesic effects of different acupoint stimulation frequencies in humans. Am. J. Chin. Med.  31: 157-162.
  13. Dey, L., Xie, J.T., Wang, A., Wu, J.A., Malechar, S.A. and Yuan, C.S.  2003.  Anti-hyperglycemic effects of ginseng: Comparison between root and berry.Phytomedicine 10: 600-605.
  14. Xie, J.T., Wang, A., Mehendale, S., Wu, J.A., Aung, H.H., Dey, L., Qiu, S. and Yuan, C.S.  2003.  Anti-diabetic effects of Gymnema yunnanense extract. Pharmacol. Res. 47: 323-329.
  15. Shao, Z.H., Becker, L.B., Vanden Hoek, T.L., Schumacker, P.T., Li, C.Q., Zhao D., Wojcik, K., Anderson, T, Qin, Y.M., Dey, L. and Yuan C.S.   2003.  Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes. Pharmacol. Res. 47: 463-469.
  16. Xie, J.T., Mehendale, S., Maleckar, S.A. and Yuan, C.S.  2003.  Resibufogenin induces cardiac antiarrhythmia.  Orient. Pharm. Exp. Med. 3: 51-55.
  17. Shao, Z.H., Xie, J.T., Wojcik, K., Li, C.Q., Vanden Hoek, T.L., Schumacker, P.T., Becker, L.B., Hamann, K., Qin, Y.M. and Yuan C.S.  2003.  Grape seed proanthocyanidins induces pro-oxidant toxicity in cardiomyocytes.  Cardiovasc. Toxic. 3: 331-339.

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2002

  1. Shao, Z.H., Vanden Hoek, T.L., Qin, Y., Becker, L.B., Schumacker, P.T., Li, C.Q., Dey, L., Barth, E., Halpern, H. Rosen, G.M. and Yuan C.S.  2002.  Baicalein attenuates oxidant stress in cardiomyocytes.  Am. J. Physiol. 282: 999-1006.
  2. Yuan, C.S., Wei, G., Foss, J.F., O’Connor, M, Karrison, T., and Osinski, J.  2002.  Effects of subcutaneous methylnaltrexone on morphine-induced peripherally-mediated side effects: A double-blind randomized placebo-controlled study.  J. Pharmacol. Exp. Ther. 300: 118-123.
  3. Yuan, C.S., Wu, J.A. and Osinski, J.  2002.  Ginsenoside variability in American ginseng samples.  Amer. J. Clin. Nutr.  75: 600-601.
  4. Dey, L. Attele, A.S. and Yuan, C.S.  2002.  Alternative therapies for type 2 diabetes.  Altern. Med. Rev. 7: 45-58.
  5. Yuan, C.S., Dey, L., Xie, J.T and Aung, H.H.  2002.  Gastric effects of galanin and its interaction with leptin on brainstem neuronal activity.  J. Pharmacol. Exp. Ther. 301: 488-493.
  6. Xie, J.T., Aung, H.H., Wu, J.A., Attele, A.S. and Yuan, C.S.  2002.  Effects of American ginseng berry extract on blood glucose levels in ob/ob mice.  Am. J. Chin. Med. 30: 187-194.
  7. Attele, A.S., Zhou, Y.P., Xie, J.T., Wu, J.A., Zhang, L., Dey, L., Pugh, W., Rue, P.A., Polonsky, K.S. and Yuan., C.S.  2002.  Anti-diabetic effects of Panax ginseng berry extract and identification of an active component.  Diabetes51: 1851-1858.
  8. Dey, L. and Yuan, C.S.  2002.  Complementary and alternative therapies for obesity.  Orient. Pharm. Exp. Med. 2: 17-27.
  9. Choi, J., Conrad, C.C., Malakowsky, CA, Talent, J.M., Yuan, C.S. and Gracy, RW.  2002.  Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines. Biochim. Biophys. Acta 3;1571: 201-210.
  10. Lee, M.K. and Yuan, C.S.  2002. St. John’s wort (Hypericum perforatum), and ginseng (Panax ginseng, Panax quinquefolius)  In: Essence of Anesthesia Practice. (Roizen, M.F. and Fleisher, L.A. eds.) 596-610. Saunders Company: New York.
  11. Yuan, C.S., Attele, A.S., Dey, L., Lynch, J.P. and Guan, X.  2002. Transcutaneous electrical acupoint stimulation potentiates analgesic effect of morphine.  J. Clin. Pharmacol. 42: 899-903.
  12. Xie, J.T., Zhou, Y.P., Dey, L., Attele, A.S., Wu, J.A., Polonsky, K.S. and Yuan, C.S.  2002.  Panax ginseng berry extract reduces blood glucose and body weight in db/db mice.  Phytomedicine 9: 254-258.
  13. Xie, J.T., Maleckar, S.A. and Yuan, C.S.  2002.  Resibufogenin, a single compound isolated from toad venom, can induce cardiac toxicity.  Herb. Complement. Med. 3: 24-28.
  14. Attele, A.S., Shi, Z.Q. and Yuan, C.S.  2002.  Leptin, gut, and food intake. Biochem. Pharmacol. 63: 1579-1583.
  15. Xie, J.T., Maleckar, S.A. and Yuan, C.S.  2002.  Beneficial and adverse effects of toad venom, A traditional oriental medicine.  Orient. Pharm. Exp. Med. 2: 21-35.
  16. Osinski, J., Wang, A., Wu, J.A., Foss, J.F. and Yuan, C.S.  2002.  Determination of methylnaltrexone in clinical samples by solid phase extraction and high performance liquid chromatography for pharmacokinetic study.  J. Chromatogr. B. 780: 251-259.
  17. Yuan, C.S.  2002.  Anti-diabetic and anti-obese effects of ginseng: From root to berry.  In: Advances in Ginseng Research (Baek, N.I. ed.) 129-144. The Korean Society of Ginseng: Seoul.
  18. Dey, L., Zhang, L. and Yuan, C.S.  2002.  Anti-diabetic and anti-obese effects of ginseng berry extract: Comparison between intraperitoneal and oral administrations.  Am. J. Chin. Med. 30: 645-647.
  19. Xie, J.T., Mehendale, S., Maleckar, S.A. and Yuan, C.S.  2002.  Is ginseng free from adverse effects?  Orient. Pharm. Exp. Med.  2: 80-86.
  20. Yuan, C.S., Dey, L., Wang, A., Aung, H.H. and Ang-Lee, M.K.  2002.  Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation.  Planta Medica 68: 1092-1096.

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2001

  1. Ang-Lee, M.K., Moss, J. and Yuan, C.S.  2001.  Herbal medicines and perioperative care.  JAMA 286: 208-216.
  2. Shao, Z.H.,  Li, C.Q., Vanden Hoek, T.L., Becker, L.B., Schumacker, P.T., Attele, A.S., Zhang, L., Xie, J.T. and Yuan C.S.  2001.  Qian-Kun-Ning, a Chinese herbal medicine formulation, attenuates mitochondrial oxidant stress in cardiomyocytes.  J. Ethnopharmacol. 74: 63-68.
  3. Xie, J.T., Dey, L. and Yuan, C.S.  2001.  Biphasic effect of cardiac glycosides on action potential duration in isolated purkinje fibers.  Pharmacol. Toxicol.89: 145-148.
  4. Yuan, C.S., Wang, X., Wu, J.A., Attele, A.S.  2001.  Effects of Panax quinquefolium L. on brainstem neuronal activities: Comparison between Wisconsin-cultivated and Illinois-cultivated roots.  Phytomedicine 8: 178-183.
  5. Wu, J.A., Attele, A.S., Zhang, L. and Yuan, C.S.  2001.  Anti-HIV activity of medicinal herbs: Usage and potential development.  Am. J. Chin. Med.  29: 69-81.
  6. Xie, J.T., Dey, L., Wu, J.A., Lowell, T.K. and Yuan, C.S.  2001.  Cardiac toxicity of resibufogenin: Electrophysiological evidence.  Acta Pharmacol. Sin. 22: 289-297.
  7. Yuan, C.S. and Dey, L.  2001.  Multiple effects of American ginseng in clinical medicine.  Am. J. Chin. Med. 29: 567-569.
  8. Liu, D., Li, B., Attele, A.S., Kyle, J.W. and Yuan, C.S.  2001.  Voltage-dependent inhibition of brain Na+ channels by American ginseng.  Eur. J. Pharmacol. 413: 47-54.

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2000

  1. Yuan, C.S., Foss, J.F., O’Connor, M., Osinski, J., Karrison, T., Moss, J. and Roizen, M.F.  2000. Methylnaltrexone for reversal of constipation due to chronic methadone use: A randomized, controlled trial.  JAMA 283: 367-372.
  2. Yuan, C.S. and Foss, J.F.  2000.  Methylnaltrexone: Investigation of clinical applications.  Drug Dev. Res. 50: 133-141.
  3. Yuan, C.S. and Foss, J.F.  2000.  Antagonism of gastrointestinal opioid effects.  Reg. Anesth. Pain Med. 25: 639-642.
  4. Yuan, C.S., Foss, J.F., O’Connor, M., Karrison, T., Osinski, J., Roizen, M.F. and Moss, J.  2000.  Effects of enteric coated methylnaltrexone in preventing opioid-induced delay in oral-cecal transit time.  Clin. Pharmacol. Ther. 67: 398-404.
  5. Yuan, C.S, Attele, A.S., Zhang, L., Lynch, J.P., Xie, J.T. and Shi, Z.Q.  2000.  Leptin reduces body weight gain in neonatal rats.  Pediatr. Res. 48: 380-383.
  6. Yuan, C.S, Attele, A.S., Dey, L. and Xie, J.T.  2000.  Gastric effects of cholecystokinin and its interaction with leptin on brain stem neuronal activity.  J. Pharmacol. Exp. Ther. 295: 177-182.
  7. Xie, J.T., Yuan, C.S., Zhou, Z. and January, C.T.  2000.  Enhancement of delayed afterdepolarizations and triggered activity by Class III antiarrhythmic drugs: Multiple effects of E-4031 and dofetilide.  Meth. Find. Exp. Clin. Pharmacol. 22: 67-76.
  8. Zhang, L., Yue, Y.T., Xue, Y.X., Attele, A.S., and Yuan, C.S.  2000.  Effects of Qian-Kun-Nin, a Chinese herbal medicine formulation, on HIV positive subjects: A pilot study.  Am. J. Chin. Med. 28: 305-312.
  9. Xie, J.T., Attele, A.S. and Yuan, C.S.  2000.  Effects of resibufogenin, from toad venom on isolated Purkinje fibers.  Am. J. Chin. Med. 28: 187-196.
  10. Xie, J.T., Lowell, T.K. and Yuan, C.S.  2000.  Extracellular detection of triggered activity of cardiac fibers using signal averaging technique.  Acta Pharmacol. Sin. 21: 977-985.
  11. Attele, A.S., Xie, J.T. and Yuan, C.S.  2000.  Treatment of insomnia: An Alternative Approach. Altern. Med. Rev. 5: 249-259.
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